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What Lactate is & What it ACTUALLY does: 5 Min Phys

October 12, 2019


Dr. Andy Galpin here
we’re back with another episode of five minute physiology where I take important
topics from things like contrition exercise strength and conditioning and
physiology and break them down and give you the needy greedy in five minutes or
less today’s topic lactate metabolism like
they took my favorite molecules of all time because you can’t read a magazine
go to the gym reflect a football game without hearing someone talked about
lactic acid buildup and are clearing the lactate out the day after a hard workout
with your still sore or some nonsense like that and it makes me laugh makes me
feel bad for Portal active because everyone hates it right it’s the bane of
your existence to some reason why you failed so I wanted to make this short
video to help you understand a little bit more about lactate so you understand
what it actually is and you can stop blaming it for all your crappy problems
your athletic problems and now I’m just gonna give you a quick shot of in this
video if you this excited to hear more about a check out the 25 minute
remaining 45 minute physiology videos I mean I liked it but I understand was
basically happening here have to realize that black CD is is a byproduct of
metabolism so it’s only being generated in other words when you break down
glucose for fuel ok glucose is basically the same word as sugar or carbohydrate
in this sense right and and in this particular talk we’re talking about
human skeletal muscle on exercise but we do that we’re seeing here is
carbohydrate is the word itself carbon and hydrate you can see from the picture
here what I’m talking about is glucose specifically is a six carbon chain so
it’s six carbons and six waters garbo yeah when I break down glucose for
energy that process to call glycolysis ok it splits into two separate three
carbon molecules called pyruvate now I make a little bit energy here but I had
to invest some into it to get there so in other words I spent $5 I made $10 so
I net gain five bucks now what you’re gaining this particular cases some
energy used to form a molecule called Google
ATP ATP is the energy currency for all of biology human not human does it
really matter fact it’s the same currency they using your red blood cells
to generate energy your brain your skeletal muscle so you can see we make a
little bit ETP right over here in the corner ok now we realize that we spent
five we gained 10 we didn’t $5 I can’t live a $5 so we’re not really trying to
make ATP here we’re trying to make pyruvate so that we can use that to make
them more EGP later if we have oxygen available we can ship the pyruvate to
the mitochondria that can be converted into another little molecule that can go
through thing called the TCA or citric acid cycle then go on to electron
transport chain and that’ll generate up to launch of ATP in fact it’s probably
10 or 20 for the ATP created here and we went through glycolysis and the very
beginnings this is the real endgame unfortunately this process doesn’t work
if i dont have the option is there is a requirement to go in the mitochondria
and that’s a requirement of course of a row vector oxidative metabolism so what
your body says it’s ok look what all do is start shifting pyruvate over to
something else now we have to understand she is what hydrogen is kinder gentler
often referred to as a proton which is H plus thats asset so pH at which stands
for potential hydrogen in other words if you have a lot of free-floating acid a
free-floating hydrogen you are acidic ok so you start taking your pyruvate East
are saying year ago I know of dinner in a bunch of acid picture yourself on that
awful paradigm bike right that’s in our house we have a saying that there’s no
winning with your time only losing its the worst exercising every its awesome
adjustments picture yourself you’re on the air and I you doing something like
twenty seconds as hard as you can twenty seconds off and you do ten rounds out or
something like we did the other day and you generate a bunch of asset what you can do the start
attaching that asset to the pyruvate now because it’s not free floating around it
doesn’t cause an acidic environment when we take a pyruvate and attach an H plus
two hydrogen protons we call that new molecule liked it really is it’s a
pirate but that’s holding on to higher than for you so not only is likely not
causing all of your problems don’t blame it for all your weekend standards it’s
actually being a buffer in other words it’s stopping you from becoming acidic
because it is holding on to a hundred and proved I can also learn because it
is simply it is just pyruvate with hydrogen if I can bring some 02 into the
arena I can combine a couple of hydrogens with that option I just
brought in and make h2o and so I can pure hydrogen back off of the lactate
combined with a to make water and it once I’ve left the hydrogen I’m not back
in my pyruvate state which is an amazing former sugar it can also be used as a
homeowner signaling molecule to tell the rest of your body and other tissues for
a system what’s going on so we can ship lactate to other exercising muscles that
aired I don’t burn really hard on my qualms I can ship lactate to say my
shoulders or something like that they can strip the hydrogen by combining with
oxygen and make them give themselves some free sugar we do the same thing at
the heart and the same thing actually what the liver in a process called the
quarry cycle we actually go through gluconeogenesis and we take to lactate
combining together and make a brand-new glucose molecule what some of the recent
research is actually showing is at your brain will do the same thing so your
brain that we know primarily runs off of glucose metabolism and since the lactate
is basically a broken down glucose if we have watched in our brain we can combine
it make water make pyruvate and power your brain this is probably why we know
that things like cognitive function memory are improving kids or people
taking final exams Sams or perform better job when you work
out really hard you are directly creating lactate which directly fuels
your brain many questions about this let me know on social media at the Dr NE
Galpin if not on my website you can go to my website to check out more of these
times of videos anti-government dot com

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43 Comments

  • Reply Sean Emery June 2, 2016 at 6:20 pm

    "Don't blame it for all your weak ass endurance." Priceless.

  • Reply Left anti pc February 25, 2017 at 2:20 pm

    This is too academic, I am left clueless after I watched the whole video

  • Reply Luke Olsen February 28, 2017 at 10:22 pm

    Out of curiosity, is it lactate which is produced or is it lactic acid which is produced which is subsequently rapidly dissociated to a lactate and H+?

  • Reply Pascal Prevost April 1, 2017 at 2:38 pm

    Two remarks to complete and modify this video because there are two mistakes :
    1°) "Lactic acid" does not exist in muscle or brain or liver.
    2°) The end product of glycolysis is LACTATE not PYRUVATE.
    Lactate can enter in mitochondry via membrane transporter (MCT) and dissociated in pyruvate + H+.
    Then, pyruvate enters in the Krebs cycle and H+ in the oxydative phosphorylation chain.
    To better understand this demonstration, please read the following article :
    https://www.researchgate.net/publication/273638624_Lactate_is_always_the_end_product_of_glycolysis
    https://www.researchgate.net/publication/312548697_Effects_of_Systemic_Metabolic_Fuels_on_Glucose_and_Lactate_Levels_in_the_Brain_Extracellular_Compartment_of_the_Mouse
    https://www.researchgate.net/publication/269186683_Cerebral_Glycolysis_A_Century_of_Persistent_Misunderstanding_and_Misconception
    Regards

  • Reply CJ May 13, 2017 at 3:52 pm

    insightful, cheers

  • Reply wilman santa cruz June 15, 2017 at 4:59 pm

    awesmone doc, I a Triathlete and coach as well, i hav alot of problems with cramps so i have hear story here and there its nuts,, any suggestion

  • Reply Fruit Cake September 3, 2017 at 9:20 pm

    nice idea, but its way to academic and so not understood by people with very limited biological knowledge.  I never understood a word, despite being quite smart and also being a gym person!

  • Reply Vimal Krishna October 7, 2017 at 6:02 pm

    Very good explanation. I got answer what I wondered for long time.

  • Reply James Bennie October 15, 2017 at 3:16 pm

    I listened to you on Joe Rogan's podcast and I must say you were brilliant!

    I came here to check out your rebuttal to the trolls you mentioned in the podcast and watched this video first. Gotta tell ya' it was great; simple, straightforward and no nonsense!

    I'm a physician trying to educate my patients how not to be patients and always showing them EduVideos (like NutritionFacts.org). You information will be one of my recommendations/reesources for people who want to understand more about human physiology.

    We need more people like you educating the public. You follow THE most important principle of science: DO NOT let your opinion(s) skew the data. Or as Neil Degrasse Tyson would say, "Science doesn't care about our opinion."

    Keep up the great work!

  • Reply zone angel November 1, 2017 at 7:07 pm

    You lost me just before ATP

  • Reply Aqhi007 November 4, 2017 at 3:38 am

    Understood. Better lecturer than uni lecturers

  • Reply Kelly J November 17, 2017 at 12:18 pm

    Great video! Why might someone with multiple sclerosis have higher lactate levels? I'm trying to wrap my head around this idea:

    https://multiplesclerosisnewstoday.com/2016/03/23/lactate-levels-tied-to-disease-progression-in-ms-indicating-mitochondrial-dysfunction/

  • Reply Octavia Henderson November 17, 2017 at 7:45 pm

    Dr. Andy, you just gave the BEST explanation I've ever heard! Thanks so much for sharing. Following now!

  • Reply Scott Printz January 2, 2018 at 5:53 am

    Hey Dr. Andy – great video! What are your thoughts on the possibility of Lactate being used directly for fuel and metabolized aerobically as per the article link by Matt Fitzgerald that I attached (referencing research by George Brooks out of Cal-Berkeley – last paragraph page 1 and beginning of page 2) ? http://running.competitor.com/2010/01/training/the-lactic-acid-myths_7938

  • Reply Alexei Montenegro January 8, 2018 at 6:57 pm

    Hi Andy. Dr. Darren Schmidt speaks about lactic acidosis like the cause of all diseases. What is your opinion on this, how to prevent it? Many thanks

  • Reply Laura Villegas January 9, 2018 at 6:26 pm

    So, I'm not a scientist. But can you clarify if any of these molecules of pyruvate are related to ketones?
    I'm having a hard time understanding what ketones are.

  • Reply david mathews March 7, 2018 at 2:34 am

    A build up of lactic acid without the removal causes muscles to cramp up. To combat this muscle fatigue is to use carnosine.

  • Reply Mark Jones April 5, 2018 at 4:13 am

    Good video, Dr. Galpin. When trying to build muscle mass, here is what seperates the men from the boys, the women from the girls…motivation and pain tolerance. When you can achieve your anaerobic/lactate threshold, and push that red line up each time, you will activate the maximum amount of motor units in a muscle cell, both red and white fibers. Maximum intensity for 1-2 minutes, right to the edge of the glycolictic pathway. Each time you force the nervous system to continue sending neurons to the neuromuscular junction when it doesn't really want to, you increase the excitation threshold, and can tolerate more discomfort each time. I have found drop sets are the best way to do this, because you can really punish the muscles, but protect the connective tissues by giving them a break on each successive drop. This is also the best way to achieve the possibility of hyperplasia.💪☺

  • Reply michaelmega1 May 13, 2018 at 10:04 pm

    is not lactose a contributor to sore and or cramped muscles?

  • Reply Daniel Jahn July 18, 2018 at 5:37 pm

    Lactic Acidosis is the primer driver of the majority of Cancers. Google Dr Darren Schmidt Lactic Acidosis.

  • Reply Nate Iowa July 25, 2018 at 3:09 am

    Would this process be the reason you struggle for the first five minutes of your workout, but seems to get easier as it goes on?

  • Reply Sec Ad August 17, 2018 at 12:17 pm

    Thank you. I need this explanation for a research topic. It's using TENS to decrease the pain sensation felt from lactic acid so one can supposedly increase repetitions. Some people stop with the pain, some tolerate the burning sensation and only stop if the muscle really fails. If TENS does work, then it might decrease the pain felt from the lactic acid

  • Reply Sheryl Marshall October 7, 2018 at 10:57 am

    I know this question will probably not get pickup , but does that mean , hydogen ions are only a problem when they don't get pickedup by the pyruvate?? Free floating ions? How does this happen?

  • Reply Elliott Hinds October 11, 2018 at 8:03 pm

    Enjoy your vids Andy. Minor detail: Pyruvate actually picks up 2 protons to become lactate.

  • Reply Jason Edwards November 28, 2018 at 2:04 pm

    wonders how eating yogurt with lactobacillus alters the lactate in blood that otherwise gets converted at the liver.

  • Reply Todd Sloan December 18, 2018 at 10:39 pm

    What I want to hear is a sick/high sugar life style does is make YOU the cancer candidate without oxygen/exercise to burn these dirty calories.

  • Reply Duck IsPVE February 9, 2019 at 1:59 am

    Would the Wim Hof method help?

  • Reply Max Williams March 9, 2019 at 9:09 pm

    Dr said lactate is good. I kept hearing that lactate was bad. They said the quicker we can get rid of it, the better we can perform. This explanation reminds me of why so many people struggle with education.

  • Reply mahchymk93 March 31, 2019 at 10:51 pm

    FUCK LACTATE

  • Reply mrclrn1 April 10, 2019 at 12:35 am

    I might sound really dumb but what is
    The difference between lactate dehydrogenase and lactate plasma blood tests. Thank you.

  • Reply Maria Valeria April 21, 2019 at 6:07 pm

    I will be graduating from nursing school in about 1 week. Currently studying for my last exam… when I was in pre-nursing, I remember learning all about this… but it did not make any sense whatsoever… NOW, after all this massive knowledge I have acquired from all the disease process studied during nursing school.. I can finally say WOW… ATP makes SO much sense in our daily lives… if only people knew more.

    Good refreshing + nice voice to hear, Thank you Andy
    Good Bless,
    MV

  • Reply Josh Gilbert April 22, 2019 at 6:06 pm

    The difference between lactate, lactose, lactic https://youtu.be/_NT8At5khQ4

  • Reply Mike Hodgson April 24, 2019 at 11:42 am

    Really helpful. Thanks Andy.

  • Reply Yeow Mun Wong May 5, 2019 at 12:46 pm

    Hi Does it mean that if I am fat adapted and use fat as energy, less lactate is produced?

  • Reply Liubov Brown May 13, 2019 at 2:28 am

    Great explanation! Thank you!

  • Reply antone yenn May 15, 2019 at 10:24 pm

    I blame lactate for my marital problems.

  • Reply Tropiicz May 30, 2019 at 12:18 pm

    Everyone in the comments is a virgin like this if u agree

  • Reply Caroline Best June 3, 2019 at 2:02 pm

    So I heard from this that lactate isn't bad no matter how much you have in your body is that correct as it can be used for fuel? So what is lactic acidosis? I always heard that it was a bad thing and is it connected to lactate? Is lactate and lactic acid the same thing? I'm a bit confused. 😕

  • Reply Richard Price June 17, 2019 at 7:13 pm

    Brilliant absolutely great but you need to zoom out and seeing a bigger picture ! breaks down int lactic acid which then poisons the cell unless it is able to be metabolized lactic acid is why it is very dangerous ! A cramping heart is a heart attack der !!!

  • Reply hinrich dorado August 15, 2019 at 6:18 am

    Simple Video! 🙂 Thank You

  • Reply Shy Riven OTP September 20, 2019 at 12:08 pm

    Bless

  • Reply Suzanne Salinas September 24, 2019 at 7:20 pm

    OK I just snap'd your "DONT BLAME IT ON YOUR WEAK ASS INDURANCE" – well said. Dying laughing.

  • Reply Pavel Pavlov October 2, 2019 at 12:00 am

    Good video. But I would disagree about the statement that pyruvate becomes lactate in the absence of O2. Even at rest or low intensity exercise we produce lactate when we have more than enough O2. Lactate production is required to generate NAD molecule, NAD is needed for the glycolysis to keep working.

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