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Vitamin D in the insulin resistant

October 10, 2019


When you’re insulin resistant, that is you’ve
got metabolic syndrome, pretty much every chemical in the body is NOT QUITE RIGHT. Some
are up. Some are down. Few are actually at physiologically NORMAL levels. Traditionally
the focus is on the big guns, sugar, insulin and cholesterol. In this series, we’ll take
a look at some of the other players. Who they are, what they’re up to and how they’re
part of the state of insulin resistance. In this video, we take a look at vitamin D, when
you’re insulin resistant, serum vitamin D levels, are often lower, than ideal. Now,
although WE refer to vitamin D, as a vitamin, because we get it in food, food is not the
official source of vitamin D. We make it ourselves, in our skin. Basically we turn skin cholesterol,
into vitamin D, when we expose our skin, to high enough levels of UVB. Since we make it,
it’s strictly speaking not a vitamin. A more accurate, description of what vitamin
D is, is it is hormone, that is it is a signalling molecule. It signals to pretty much every
cell in the body, via the vitamin D receptor. It turns out, what we make and or eat, which
is also known as calciferol, is not quite a hormone, in order for it to be a hormone,
a little chemistry has to happen. Step number one, takes place in the liver. The liver pops
a hydroxyl group onto the vitamin D, making it 25hydroxy vitamin D, or calcidiol. Now
this is exciting, but not enough to make the vitamin D, a fully fledged hormone. To be
a full fledged hormone, the kidney, also has to pop on a hydroxyl group, to make 1,25 dihydroxy
vitamin D, also know as calcitriol. Only then is vitamin D, ready to be a hormone. Now,
the first step in the process is not strictly controlled, but step two is, so your body
makes sure you get, just the right amount of vitamin D. And the “right” amount,
depends on your calcium status, which depends on your genes and lifestyle. Now vitamin D,
the hormone, works hard. Scientists reckon over 900 genes, take their orders from vitamin
D, via that vitamin D receptor, and vitamin D receptors are ON virtually every cell in
your body. Something SO powerful, MUST BE a controlled substance. So what do blood tests
measure ? Well, the blood test that is routinely used, to test your vitamin D status, is measuring
how much pro-hormone is in the circulation, not how much of the active hormone is around.
This means, you could have low calcidiol but normal calcitriol or you could have low calcidiol,
plus low calcitriol. Only in one of these scenarios are you genuinely deficient. You
end up in this scenario, mostly if you don’t get enough sun, in this is the case, you do
need more calciferol. But, before you reach for that vitamin D supplement, it is important
to realize, just like you store calories for a rainy day, you also store vitamin D, for
sun less days. Something that is a reality, in winter. Now, the spot where the vitamin
D is stored – is your fat cells. So the more fat cells you have, the bigger your capacity
to store vitamin D. You don’t need more calciferol. Having said that, to get the vitamin
D out, is an active process. Now, if you’re not in the habit of burning fat, which you’re
not, when you’re insulin resistant, odds are, you’re not releasing much of that vitamin
D store. The point being, adding more, of something you’re not short of, doesn’t
make sense. And might in the long run, be harmful. There are now half a dozen, clinical
trails, that have shown, supplementing with vitamin D, does not improve body chemistry,
in those who are not genuinely short of vitamin D. And too much vitamin D, can be just as
big a problem, as too little, it raises the levels of calcium, circulating in your blood.
Now this calcium can be deposited in your bones, which is good. But, it can also be
deposited in your blood vessels, turning your blood vessels, to stone. Inflexible blood
vessels are unable to expand and contract as the blood whooshes – this contributes
to rising blood pressure levels and eventually pipe bursts. A problem, that goes hand in
hand, with insulin resistance. Keeping tabs on your vitamin D status is healthful. If
you’re genuinely deficient, supplement to “fix” it. The universally agreed upon
level, which is considered to be deficient, is a level of 25 hydroxy vitamin D, less 10
ng/ml. At these levels, your blood levels of calcium, will be low and parathyroid levels
will be elevated, putting your bones in jeopardy. But, when your levels are not extremely low,
the biology suggests that you should proceed with caution, you want enough vitamin D, not
too little and not too much. The optimum way to get vitamin D, is the way Mother Nature
intended, through sun exposure. Now, small doses of sun, are not risky, sun burns are.
Exactly how much sun you need to turn up vitamin D production depends on your skin tone, how
much of you is catching the sun, the season and your geography. You can’t over do it.
And, since the sun does a whole lot more than just make vitamin D, the benefit to your body
chemistry will be extend way beyond, vitamin D production. If circumstances make getting
your vitamin D fix, from sun tanning, an impossible proposition. Then, you need to “eat” it.
Foods considered high in vitamin D, include fish and eggs. Plan C would be to supplement,
this should be medically supervised and for a shorter period, as it necessary. Epidemiological
studies, do suggest, that running low on vitamin D levels, is a sign of bad body chemistry,
but this does not mean, it is the cause of bad body chemistry. And you cannot fix it,
by taking excessive amounts of a vitamin D supplement. You need to “fix” the underlying
body chemistry that is keeping it low, this may take a little detective work. Here are
a few of the journal articles I’ve used to tell the vitamin D story. Vitamin D is
just one of hundreds of chemicals in the body that are amiss when you’re suffering from
metabolic syndrome. You can learn more about some of them, in our Ups and Downs of Insulin
Resistance series. Be sure to subscribe to our channel to catch future episodes. Thank
you so much for watching and I’ll see you next time.

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3 Comments

  • Reply Prince A July 25, 2019 at 12:03 am

    Very good channel. great work.. the only thing that held the channel from growing is accent. It's needed to be improved to grow the channel exponentially..

  • Reply Steve Jones July 25, 2019 at 12:15 am

    Great channel!

  • Reply Marilyn du Kek July 26, 2019 at 1:13 pm

    Pediatricians are now recommending giving babies vitamin D drops, what are your opinions about that?

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