Articles, Blog

The Information Theory of Aging: David Sinclair’s Book LIFESPAN (Part 1)

October 12, 2019

So I get a lot of comment and views on
the David Sinclair books. I get comments about David Sinclair even on other
videos. For example, John Tocho. “In David Sinclair’s book LIFESPAN page
304 he uses NMN and not NR. He believes that NR, while not as expensive, does not provide as much benefits as NMN.
Dr. Brewer, I hope that you will read LIFESPAN by Dr. Sinclair and do a review
for us like you have other books. Thank you.”
Well John, that’s exactly what I’m going to do. I read David Sinclair’s book LIFESPAN
and this is a review of the book of David. It’s a long book. He goes into his
background, describes that, then he goes into his experience at MIT and his
experience in terms of coming up with what he calls the “informational theory
of aging.” That’s a big transition. The reigning theory for aging for decades
has been the mitochondrial theory. The mitochondria are where we do the oxygen
level of burning. The oxygen level of which we get most of our energy and that causes
oxidation. And hence, antioxidants and all of that chase for using antioxidants
to prolong lifespan. He goes in, he goes into what I think makes a lot of sense.
He basically says what happens is our genes don’t change but we lose our
ability to read them and that’s what one word: epigenetics. So it makes a good
discussion of his theory of the informational reasons for aging. Then he
goes into some details about different types of techniques like metformin. I
don’t think we’ll have a lot of time to cover metformin in this video but I’ve
covered it in others and I’ll cover it again just to get into a little bit more
detail. Then he talks about other supplements that he’s working on ones
that he’s tried in the past like resveratrol and NMN. So let’s go back
to his background MIT postdoc. Tenured faculty at Harvard and then and New
South Wales he started in New South Wales he was born in either run that way
he’s born in New South Wales I’m pretty sure he talks about his grandma who was
a Jewish immigrant from Eastern Europe fled the communist rule there and he
missed her. And as a very very young man like four or five years old, he got very
concerned about her dying and then other people dying and he never got
could got over that concern about death and longevity. In 2002, he discovered a
key role of NAD+ in aging, co-discovered sirtuins, resveratrol and STACS. STACS
have to do with again control of information, epigenetics, how our body
reads our DNA. On March 2017, he discovered NMN. Now
he goes into some of the hallmarks of aging, things that we’ve heard about
before multiple times: telomere attrition, stem cell exhaustion, cellular senescence
(or what are popular being popularly maybe that’s not a word but are being
called “zombie cells”), epigenetic alterations, mitochondrial dysfunction,
genomic instability talks about getting up. You know like all of us have had some
sort of when you get one of those genius events, he described one of his genius
events that you woke up early in the morning, couldn’t go back to sleep. He
kept thinking about all of the different things that he was finding in those
spaces and he said, you know what, it’s like a demented pianist. Imagine you’re
in a concert hall and hearing a pianist do Mozart or some other classical music
doing great and then all of a sudden you hear a little tink that’s not part of
that music. Doesn’t make any that much of a difference but then you hear it again
and then again and then more of it and more of it stuff that’s not really in
there. And he goes on to talk about that’s actually what’s happening with
our epigenetics. As we need as we have as we pull out parts of our genes using our
epigenetic mechanisms using our gene expression mechanisms, there’s a huge
librarian type of activity you have to unpack that the DNA for that gene you
have to recreate it for or translate it into RNA or and then transcribe it into
proteins. Well all of that involves a lot of replication. It’s like using copy machine at the library to do mass
copy. Just imagine that like that demented pianist,
the copying machines start running amok and that’s what he describes. He says, look there Werner mutants and Werner mutants were
laboratory animals, lab mice, that had Werner’s syndrome which is a genetic
problem where you age very rapidly. A five-year-old Werner syndrome person will
look totally normal by age 20 though they look like an old person and they
usually die in their 40s. What’s going on is the Werner mutants
were madly unpacking like a vacuum sealed bag of yarn their DNA. Like a
vacuum sealed bag of yarn that had been ripped open. He then goes on to describe
those loops a little bit more deeply called Emes ERC loops. “NAD-boosting
SIRT1 resulted in the intima cells of elderly mice were pushing into
multiple muscle tissue, providing needed blood supply. Because if sirtuins had
been activated, the epigenomes were becoming more stable, age reversal.” In
other words, these geriatric mice were becoming ultramarathoners. In other
words, these mice were aging. They were developing this ERC DNA loops, they were
giving them a couple of things, they were impacting their SIRT1. The
SIRT1 are things that control this packing process then they were reversing
that that aging process. So he’s making the point and he’s seeing it in his labs
and that’s what he’s talking about: not only can we slow down aging, we can
actually reverse it. So his goal is to make that Jewish blessing that says, “May
you live into your 120.” Obsolete because it’s sort of like today, saying “May you
live till you’re 60” now, is that really crazy? Mm-hmm.
He makes a really good case that it’s not and I will tell you this even before
I read that book, I’m constantly telling people, “Look you need to expect to live
to your 90s.” So many people have come to me with significant calcium scores and
they’re saying you can tell that’s just difficult for them to believe. I tell you
what. Read the book LIFESPAN. It goes into a lot of detail on wine that’s not so so
outlandish. Thank you for your interest. I’ve had so many patients come to me
because they quote their diet here, why don’t you take this statin and let’s see
what happens what, let’s see if a heart attack or stroke happens. No, prevention
is a science. We know what’s going to happen. We know what to look for. We know
how to prevent it. Come see us in Louisville on November 8th and 9th. Get
your CIMT artery scan all your labs, see me and spend two days learning usually
what your doctor doesn’t know yet about the science of prevention. Look forward
to seeing you there. Thanks.

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  • Reply Ali Activ Plus - Tongkat Ali October 8, 2019 at 3:02 pm

    Interesting! Everyone wants to stay young forever if possible.

  • Reply farrokh farr October 8, 2019 at 3:24 pm

    more information for my hungry and lazy mind. thank you good doctor .

  • Reply Daniel Christopher October 8, 2019 at 3:28 pm

    Thanks Dr Brewer, I have watched Dr sinclair several time, he is a facinating person.

  • Reply Radnally October 8, 2019 at 3:30 pm

    They seem to know a lot about how the mechanism of aging happens. But, manipulating it is evasive.

  • Reply Dave Oatway October 8, 2019 at 4:21 pm

    I read Dr Sinclair's book. Your review was very accurate. I did also enjoy his excursion into philosophy, politics (non-partisan) and economics of increasing health and life span. I'm a 75 yo wm. I walk 5-10 miles a day ( more when hiking mountains like the Andes) and do low carb with intermittent fasting. I do 2 hours in the gym a week.

     I have been taking NMN 250 mg bid and NR 250 mg bid, with Resveratrol, and K2 Mk7 for over 9 months. I have great energy, doing some of the most complex analyses I have ever done – fortunately my client values my years of experience and perspective and wants his younger staff mentored.

    One interesting side effect that I ascribe to the NMN/NR is my hair. A year ago I was completely light gray. Now my daughter accuses me of coloring it brown! Thank you again for your thoughtful insights.

  • Reply xxx xxx October 8, 2019 at 5:04 pm

    I'm sure like all his videos his theory would be he uses :

    Intermittent Fasting

  • Reply John Panozzo October 8, 2019 at 7:02 pm

    It's very helpful to have someone who is an expert and who you respect review the latest medical literature, regardless of format be it journal article, book, website ,etc., and provide their educated opinion. Thank you Dr. Brewer.

  • Reply Gigi Friedman October 8, 2019 at 11:17 pm

    Speaking of aging well, I just got back from a trip to Minnesota to see family. We took my 88 year old aunt out to lunch. (I had soup and small salad, she ordered soup and a hamburger on a rather large, shiny Kaiser bun) She has diabetes and is on Metformin only. She told me that her doctor told her to keep her glucose numbers between 160 and 200. My eyes widened, and then I thought, who am I to question that…lol..and decided not to go into my medical diatribes at that point. After all, she is 88 years old and I am not! 🙂 She is in good health and her face is youthful. However, numbers between 160 and 200?? But she’s 88 and thriving…

  • Reply Steve Hubbard October 9, 2019 at 12:10 am

    Dr Brewer, wonderful summary. When my weight and traditional blood/urine markers are stabilized, I will next consider these advanced anti-aging ideas.

  • Reply Ron Wells October 9, 2019 at 1:51 am

    Thanks for your help, please do one on ED, thirty million men tonight will go to bed in the USA, with this disfunction,Thanku

  • Reply jointstrike2 October 9, 2019 at 2:04 am

    I've always thought that cancer is a low signal to noise ratio.

  • Reply lance h. October 9, 2019 at 3:15 am

    Well at first thought I said wow wouldn't it be great to live to be 120! But then i got to thinking if i live to be 120 in the present economy that means i can't retire until i am about 105 which in turn means i will have to work at Walmart for another 48 years… I think i will stick to my 75 year package.

  • Reply Marcus Glading October 9, 2019 at 6:44 am

    Sinclair has a great interview with Peter Attia if anyone needs more detail

  • Reply Jonathan Lynch October 10, 2019 at 12:51 pm

    A suggestion on framing headshots on camera – position the camera so that your eyes are 1/3 of the way down from the top of the screen. Former CNN producer.

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