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Gymnema sylvestre: Sugar Destroyer & Sweetness Blocker? (Part 2)

September 12, 2019


Gymnema sylvestre and thought you might
be interested in how they work or at least what’s known about how they work A little bit today about Gymnema
sylvestre it’s a supplement it’s used for to combat diabetes it’s actually
been around for several hundred years it’s been used in Ayurvedic medicine the
name comes from a hindi word called “the sugar destroyer”
it’s a woody plant woody climber it’s found in West Africa, Sri Lanka, India the
original part one that I did this is part two part one look looked at what is
it what’s it used for and does it work now they the science is not very good
around around this is just like it isn’t great around a lot of supplements just
not a lot of work done in the area if you look at the science I’ll show a
couple of the articles they’re just more descriptive type of things one of the
reasons I bring that up in terms of this discussion is the discussion of active
ingredient you’ll see that there’s a simple listed active ingredient gurmarin
or gurmar which is a 35 amino acid polypeptide or you know protein amino
acids in a row that’s a protein poly peptide peptide is the building block of proteins now you get that description of a single active
ingredient and then you get this this doesn’t look like a 35
amino acid polypeptide to me but that’s also listed as under the biochemical
name of Gymnema sylvestre and gurmar it’s also used by the way for weight
loss and laxatives or diuretics this is a typical article it’s a fairly
lightweight article no randomized clinical trials that I could find
anywhere but a lot of just descriptive type things what does it do it blocks
the sweet and sugar receptors evidently on the tongue, in the bloodstream, and
intestinal sugar receptors it may it appears to increase insulin secretion
and may actually increase Islet cell growth again fairly and a lot of claims
there but not a whole lot of science to support it with anything any
supplement you need to look at both sides look at the safety here the safety
record like most supplements is pretty pretty clean some of the things that you
see warnings about our hypoglycemia again I don’t think it’s strong enough
to be a major danger in that area but if you’re piling on a lot of different type
of glycemic and medications then yeah you could consider some risk there the
laxatives and diuretics the reasons that you gave it in the first place
pregnancy is you know there’s lists of almost everything you get very concerned
about pregnancy liver toxicity again just a couple of mentions but not a lot
of clear information so why am I covering HMG-CoA reductase that gets
into this next study HMG-CoA reductase is the action point for statins they are
also called HMG-CoA reductase inhibitors why am i mentioning that right now is
that a total out of the blue comment the reality is no it’s not you’ll see in
this in this article that I’m going to cover for this video
phytochemical and pharmacological properties of Gymnema sylvestre an
important medicinal plant it actually has an impact in this area metabolic
pathway as I covered before this this is just some follow up now
let me go back and make a comment about the molecular structure one of the
statements made by that article is how does it do the how does it block immuno
how does it blocks sugar receptors in the tongue blood and gut because
molecularly it looks like sugar here’s what sugar’s
look like molecularly glucose fructose and sucrose and I guess
you could say they look like that at least glucose is a six carbon well five
carbons in an oxygen it’s a six atom ring
most of these are six atom rings I don’t see any five
atom rings on here like you do with the with fructose and part of sucrose so hmm
and sucrose by the way is what a glucose and fructose bound together so but maybe
you know maybe your tongue and maybe the receptors think that that looks alike as
I mentioned we’ll get into why I brought up the HMG-CoA business also we’ll get
into cytochrome p450 interactions if you don’t recognize or remember that
cytochrome p450 is a metabolic pathway it’s fairly nonspecific there’s several
different cytochrome switch metabolize and are involved in in several metabolic
pathways what you can get is take one drug that stimulates the cytochrome p450
activities then take another drug that is metabolized by cytochrome p450 it can
in the two drugs can impact the dosages of each other for example phenytoin (a
seizure medicine) is an inducer of cytochrome p450 if you give donepezil or
mmm simvastatin or atorvastatin these are all drugs that are impacted by
cytochrome p450 and other cytochromes and can be can therefore impact the
dosages of each other so why am i bringing that up again just be patient
we’re gonna get there and it’s in this article
phytochemical and pharmacological properties of Gymnema sylvestre now it
says an important medicinal plant I think these guys are big fans of the
plant I’ve used it a few times I know that there’s a lot of folks that are
into supplements that are using it as well I’m not gonna re-read through the
abstract other than this last sentence “The review explores the transition of a
traditional therapeutic to a modern contemporary medication with an overview
of phytochemistry and pharmacological activities and its fight against
constituents” you hear fight over there a couple of times fight oh again just me
plant so phytochemistry means “plant chemistry” phyto constituents of plant
components of it these guys go on to mention that they’re about 45,000 plant
species in India with about 10% of them being used in endocrine activities like
diabetes it goes on to discuss other hypoglycemic drugs such as sulphonylureas and biguanides it’s biguanides metformin is a biguanide and then it
goes on to say that they’re adverse side effects sulphonylureas do actually have
some very significant adverse side effects metformin does not appear to
have the as significant side effects as we used to think at least in terms of
lactic acidosis that’s been reviewed a couple of times
but during Cochrane reviews and they really found that
doesn’t unlike the other biguanide that do so again as you continue to go
through this article it does get better in terms of the biochemistry but it’s
they paint with a fairly large brush in terms of their their assumptions I’m not
going to go into the traditional perspective the taxonomy the
phytochemical perspectives I will however show you some of the “phytoconstituents” as you see the the Gymnema appear to be an entire
class of drugs or not drugs but chemicals which are found in this plant
gymnemic acids acylated gymnema- saponins saponins alone so again without getting too deep and taking too
much time just making the point that there’s a lot of different chemicals in
this phyto soup and it’s again not quite so clear exactly which ones do what as
they mention on later well just one other point those are the chemicals that
that the earlier comments were molecularly they fit into sugar receptors and
actually blocked them so yes they’ve been researched been studied showing that
you swish and swallow Gymnema components and you can’t and then try to taste
things later and you can’t taste sugar or sweetness as well now this gets back
into you remember I asked the question a few minutes ago
oh why would I talk about statins well this is how Gymnema components are
made it starts on the mevalonic acid pathway in the cytoplasm which starts
with this acetyl CoA the third component in that pathway that’s a well
known pathway by the way the third component the third enzyme is
HMG-CoA reductase now what is that used for well you can go on to make statins
our (excuse me) LDL out of HMG-CoA and reduction HMG-CoA
reductase is how statins impacted they inhibit that activity as I showed you a
few minutes ago that’s part of the the pathway now if you go continue to go
down this pathway again you get to the Gymnema remember I also mentioned
cytochrome p450 cytochrome p450 is part of the very last couple of steps before
you get creation the Gymnema mode activities the gymnemic acids and the
other gymnema components so what does all of this mean I don’t think it’s
earth-shaking it does help those guys a lot of folks that are interested in
supplements don’t know how they work and haven’t really taken the time to look at
the research around them I know there again there are several folks who are
interested in Gymnema sylvestre and thought you might be interested in how
they work or at least what’s known about how they work if you’ve made it this far
thank you very much for your interest and if you could comment and tell me
tell me what you think about Gymnema what do you use it does knowing a little
bit more about it impact you in any way does it make you want to use it make you
want to try it make you want to stop it thanks CIMT Access Event is happening
in LA, Anaheim, September 28th with David Meinz for the full afternoon plus a full
CIMT plus the reading on it two hundred and forty five dollars thanks

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13 Comments

  • Reply trotskyite1 September 10, 2019 at 3:21 pm

    my sister in law is a prof at uni of louisville and was asking whether she could bring some nursing students to the conference? I think she'll probably get in touch through official channels to ask you.

  • Reply Jollyprez September 10, 2019 at 3:29 pm

    Doesn't any "sugar" that goes to a receptor trigger insulin secretion? Coffee black, or coffee with cream doesn't trigger insulin – but coffee with artificial sweeteners DO, apparently. Insulin starts, autophagy stops – seems like this chemical would have the same effect? Not sure what good it'll do.

  • Reply MrJoeyBoombotz September 10, 2019 at 3:34 pm

    I found that salted sauer kraut, with the tiniest amount of artificial sweetner added takes my cravings for sugar away. Every day I have one or two small mouthfuls of that sauer kraut and I don't even think of eating sugary foods.

  • Reply Guo Mashi September 10, 2019 at 3:57 pm

    Gymnema is very effective, more so than any prescribed diabetic medicine in my experience.

  • Reply James Kantor September 10, 2019 at 4:03 pm

    Can you attach link to the article you discuss, thanks.

  • Reply James Kantor September 10, 2019 at 4:09 pm

    I have been using in a product called Sugar Control Keto living by nature’s plus. I have only used one bottle for a month. But does seem to help with Metformin to help lower my blood sugar after I take it. It appears to be short acting.

  • Reply David Ivers September 10, 2019 at 4:20 pm

    Thanks, Dr.Brewer. I do not currently take it. I believe that more research needs to be done on its effectiveness before I would consider taking it. I have been trying some berberine (1500mg/day) but it doesn't seem to have a large effect if any. I've reduced my Crestor dosage to 5mg/day to see if has any effect on my fasting blood sugar. If not at the end of 90 days, I may try some Metformin. I'm a walking g experiment.

  • Reply mrytully September 10, 2019 at 4:20 pm

    scheduled cimt in La. thanks for putting that together/advertising it…

  • Reply Zero Connie September 10, 2019 at 4:54 pm

    Love your informative videos. Than you. 😽

  • Reply Franklin Taylor September 10, 2019 at 5:15 pm

    I have taken this 400mg daily since June. Still progressing well with blood sugar and weight loss goals, but I have been doing other things in tandem. Couldn't separate this herb out specifically. Maybe it is helping with cravings. They have seemed much better controlled since early summer.

  • Reply Elias Hyam September 11, 2019 at 1:13 am

    Dr. Brewer, it has helped me with my sugar cravings. Very effective.

  • Reply Secret Squirrel September 11, 2019 at 2:12 am

    Wouldn't this change the taste of foods drastically?

  • Reply Loretta Dillon-Ham September 11, 2019 at 9:06 am

    Mmmm I like this intro

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