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Gluconeogenesis as a Stress Response: Regulation by Cortisol | MWM 2.31

October 10, 2019

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10 Comments

  • Reply Nadia Al Wardy August 24, 2017 at 9:08 am

    Hi Chris. why is cortisol lower at rest on a ketogenic diet compared to a mixed diet in the Zajac study?

  • Reply Henry Stewart Music Covers August 24, 2017 at 11:08 pm

    great video as ever Chris 🙂

  • Reply Abu Sumayah Laughton August 25, 2017 at 9:46 am

    The study mentions that the ketogenic diet was HIGH in polyunsaturated fats. Would the high PUFA content not have an impact on cortisol to begin with? Furthermore, just because the cortisol was higher during exercise doesn't mean that it will stay elevated once the individual is rested.

    Another thing I'm skeptical about with the study is the macro-nutrient ratios. The study mentions both groups were eating close to 4000 calories. 15 percent carbohydrate can come to a lot of grams when its measured in percentages which makes me wonder how adapted the athletes were. Did they measure blood ketones to check that they were even in a state of ketosis? If they weren't then cortisol would definitely be elevated because the body is in an energy crisis due to a lack of the enzymes needed to succeed on a carb restricted protocol.

  • Reply Abu Sumayah Laughton August 25, 2017 at 9:57 am

    Also I haven't read much about what would be considered high and low cortisol but the variation in cortisol levels between the two groups does appear to be pretty insignificant. May be that's due to my lack of knowledge of what is considered excess. I don't know. If you are able to draw the conclusion that keto increases stress hormones, since the study shows higher levels in the keto dieters during intense exercise, then couldn't I also conclude that a mixed diet is actually more stressful, since the stress levels were shown to be higher in the mixed group during rest? Especially when you consider rest is the more common state?

  • Reply Justine Lichtenstern August 26, 2017 at 11:15 pm

    So will long term use of corticosteroids have the same affect as glucocorticoids? How about short term?

    And the English major comment. 🙁

  • Reply humanyoda September 2, 2017 at 3:09 am

    That data seems to support the claim by Paul Jaminet that glucose should provide somewhere between 20% and 40% of daily calories. This, according to him, is just right for energy and structural needs.

  • Reply Rodrigo Ferreira da Rosa November 16, 2017 at 10:14 pm

    Did the people with rheumatoid arthritis improve in the ketogenic treatment?

  • Reply Beat and Pulse June 18, 2019 at 1:50 am

    Ok it is not the nicest to say that about the degree in English at the beginning

  • Reply Ayrad160 August 19, 2019 at 2:13 am

    Conclusion : eat keto most of the time and when its time to exricse eat some carbs .

  • Reply Matt Marshall September 19, 2019 at 6:41 am

    Would chronic elevated blood sugar levels promote fatty liver disease?

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