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Blood urea and creatinine levels…. Explained !!!

August 31, 2019


In this video, I’ll talk about two important biochemical parameters That are measured in blood in order to assess the function of the kidney These two parameters are blood urea and creatinine Blood urea Blood urea is synthesized in the liver from the ammonia produced in the intestinal tract As a by product for the digestion of protein So, ammonia produced in the intestinal tract is transported to the liver and then converted into ures The urea is excreted through the kidney excreted through the kidney So, this why blood urea is used as a test for the function of the kidney The second parameter is creatinine The second parameter is creatinine Creatinine is a metabolic product produced from the muscles First, creatine is synthesized in the liver and then transported to the muscles, combined with phosphorus and result in the formation of phosphocreatine and then, when the body needs energy The phosphorus is used for synthesis of ATP and the creatine is converted into creatinine The creatinine produced from the muscles is excreted only through the kidney excreted only through the kidney So, here, these two parameters excreted through the kidney and this is why used to assess the function of the kidney However, urea is considered sensitive for renal diseases but not specific Creatinine is considered specific but not sensitive So, the presence of mild renal disease, will result in increase the level of urea in the blood why urea is considered none specific for renal diseases This because urea is affected by the levels of proteins produced in the intestinal tract when large amount of protein produced this means that more ammonia is produced and transported to the liver and will result in increase the level of urea which is not related to a disease in the kidney also, in presence of abnormalities in protein metabolism will result in reduction in the production of ammonia and affect the level of urea in the blood Also, the presence of disease in the liver will affect the production of urea and may result in reduction in the level of urea in the blood Also, another factor that affect the level of urea in the blood is dehydration Urea increased in the blood circulation in cases of dehydration or hemoconcentration So, cases associated with diarrhea or vomiting or any other causes of dehydration will result in elevation of urea level in the blood So, renal disease is not the only cause for elevation of urea However, if we excluded other causes that will result in elevation of urea The kidney will be the cause, at that time So, urea is considered sensitive it increase in mild renal diseases but, urea is not specific, because there are other factors affect the level of urea in the blood regarding creatinine Creatinine produced in muscles However, creatinine excreted only through the kidney Creatinine is not affected by the diet Creatinine is not increased in cases of dehydration So, creatinine is specific for kidney diseases but, it increased in late renal diseases not like urea so, it is specific, once creatinine increased The renal disease is confirmed Also, usually increase of creatinine is associated with elevation of blood urea However, elevation of blood urea is not is not essentially associated with elevation of creatinine levels in the blood Creatinine level in the blood can decrease in cases of wasting of, in cases of emaciation or wasting of muscles due to the decrease the muscle mass will result in decrease the production of creatinine and affect the level of creatinine in the blood So, creatinine level can be decreased in cases of liver diseases or in case of wasting condition, or decrease the muscle mass in the body Muscular structure of the body but creatinine, as we said before is considered specific for kidney diseases However urea is sensitive and not specific in conclusion Both urea and creatinine used to test the function of the kidney Creatinine is specific but not sensitive urea is sensitive but not speicifc The elevation of creatinine in the blood is usually associated with Elevation of urea However, elevation of blood urea is not essentially associated with elevation of blood creatinine levels

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13 Comments

  • Reply Hasibul official lab February 2, 2018 at 4:42 pm

    tnx

  • Reply Mohamed Naser September 23, 2018 at 11:26 am

    تسلم شرحك جميل اووى

  • Reply Bandhavya B March 24, 2019 at 12:35 pm

    My age 26
    Female,
    Urea 14
    Blood urea nitrogen 6.54
    Creatinine 0.6 tell me sir ,it's any Problem for me

  • Reply Hesham Gaber April 2, 2019 at 8:45 am

    Please my prof. can I ask how I differentiate between the causes , if I have pt. with elevation of both urea and creatinin

  • Reply amit kumar April 7, 2019 at 4:16 pm

    Age 38 male
    S Urea 20mg/dl
    S Creatinine .85mg/dl
    Is there any thing abnormal

  • Reply Sajjad Ahmad April 13, 2019 at 6:54 am

    Sir please guide me is there urea and creatinine results correlat with each other like if creatinine normal and must be urea normal. Please guide me about creatinine and urea correlation.

  • Reply mohammed nasiruddin April 23, 2019 at 4:21 pm

    Age 35
    Creatinine is 1.12 is higher or normal

  • Reply Sanjay Dubey May 2, 2019 at 7:31 pm

    Urea is normal but creatinine is high.

  • Reply Praba Vishnu May 12, 2019 at 9:20 am

    Creatinine level 0.8 normal?

  • Reply Gnaneshwar Palla June 10, 2019 at 9:27 am

    Dear sir my age 22
    My creatine… Level 0.9
    Urea level…… 11 it means

  • Reply Martin S.R.V June 29, 2019 at 7:02 am

    Blood urea 48 creative level 1.5 normal please sir

  • Reply Martin S.R.V June 29, 2019 at 7:05 am

    Please sir

  • Reply shubham singh July 15, 2019 at 8:58 pm

    Sir age is 60+ blood Urea level is 43 and creatinine 1.6 , is it normal ?

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